单项选择题
There is evidence that the usual
variety of high blood pressure is, in part, a familial disease. Since families
have similar genes as well as similar environments, familial diseases could be
due to shared genetic influences, to shared environmental factors, or to both.
For some years, the role of one environmental factor commonly shared by
families, namely dietary salt (i.e. sodium chloride), has been studies at Brook
Haven National Laboratory. These studies suggest that frequent excess salt
eating can lead to high blood pressure in man and animals. Some individuals,
however, and some rats consume large amounts of salt without developing high
blood pressure. No matter how strictly all environmental factors were controlled
in these experiments, some salt-fed animals never developed high blood pressure
whereas a few rapidly developed very serious high blood pressure followed by
early death. These marked variations were interpreted to result from differences
in genetic constitution. By mating in successive generations only those animals that failed to develop high blood pressure from salt eating, a resistant strain (the "R" strain) has been evolved in which consumption of large quantities of salt falls to influence the blood pressure significantly, in contrast, by mating only animals that quickly develop high blood pressure from salt, a sensitive strain ("S" strain) has also been developed. The availability of these two strains permits investigations not possible formerly. They provide a likely laboratory model on which to investigate some clinical (临床的) aspects of the human types of high blood pressure. More important, there might be the possibility of developing methods by which genetic likelihood of human beings to develop high blood pressure can be defined without waiting for its appearance. Radioactive (放射性的) sodium 22 was an important "tool" in working out the characteristics of the sodium chloride metabolism. |