TEXT B Two techniques have
recently been developed to simplify research and reduce the number of nonhuman
primates needed in studies of certain complex hormonal reactions. One technique
involves the culturing of primate pituitary(垂体)cells and the cells of certain
human tumors. In the other, animal oviduct (输卵管) tissue is transplanted under
the skin of laboratory primates. Both culturing techniques complement existing
methods of studying intact(完整的) animals. With an in vitro
culturing technique, researchers are deciphering how biochemical agents regulate
the secretion of prolactin(催乳激素), the pituitary hormone that promotes milk
production. The cultured cells survive for as long as a month, and they do not
require serum (血清), a commonly used culture ingredient that can influence
cellular function and confound study results. One primate pituitary gland may
yield enough cells for as many as 72 culture dishes, which otherwise would
require as many animals. The other technique allows scientists
to monitor cellular differentiation in the reproductive tracts of female
monkeys. While falling short of the long-sought goal of developing an in
vitro model of the female reproductive system, the next-best alternative was
achieved. The method involves transplanting oviduct tissue to an easily
accessible site under the skin, where the grafted cells behave exactly as if
they were in their normal environment. In about 80 percent of the grafts, blood
vessels in surrounding abdominal skin grow into and begin nourishing the oviduct
tissue. Otherwise, the tissue is largely isolated, walled off by the surrounding
skin. A cyst(囊胞) forms that shrinks and swells in tandem(一前一后的串联) with stages of
the menstrual cycle. With about 80 percent of the grafts reestablishing
themselves in the new site, a single monkey may bear as many as 20 miniature
oviducts that are easily accessible for study. Because samples are removed
with a simple procedure requiring only local anesthesia, scientists can track
changes in oviduct cells over short intervals. In contrast, repeated analysis of
cellular changes within the oviduct itself would require abdominal surgery every
time a sample was taken a procedure that the animals could not
tolerate. Scientists are using the grafting technique to study
Chlamydia (衣原体)infections, a leading cause of infertility among women. By
infecting oviduct tissues transplanted into the abdominal skin of rhesus
(罗猴)monkeys, researchers hope to determine how the bacteria cause pelvic
inflammatory disease and lesions(损害)that obstruct the oviduct. Such research
could eventually lead to the development of antibodies to the infectious agent
and a strategy for producing a Chlamydia vaccine. According to the passage, Chlamydia causes infertility in women by ______.
A.causing tissue changes which block the oviduct B.shrinking and swelling tissues in conjunction with the menstrual cycle C.allowing skin tissue to encyst reproductive tissue D.necessitating abdominal surgery to remove damaged tissue