Scientists have developed a slimming drug after years of efforts．The drug can successfully (62) appetite and result (63) a dramatic loss of weight without any apparent ill effects． The drug (64) appetite control and, as a result, (65) the build-up of fatty tissue．Laboratory mice given the drug (66) up to a third of their total body weight． Within 20 minutes of (67) the drug, called C75, the mice lost interest in eating and survived apparently content on just 10 percent of the food they would (68) eat． More (69) , the drug appears to prevent a serious (70) in metabolic rate- (71) tiredness and sleepiness which is typically (72) with living on a starving diet． As a result, mice taking the drug lost 45 percent (73) weight than mice fed the same amount of food, which compensate (74) the lack of food by becoming (75) in moving around． The scientists, from the Johns Hopkins University in Baltimore, said that C75 is likely to produce a (76) effect on humans because appetite control in the brmn is thought to be based largely on the same chemical paths as (77) in mice． "We are not declaring to (78) the famous weight—loss drug． (79) we have found, using C75, is a major path in the brain that the body uses naturally in bringing order to appetite at least in mice, "said Francis Khan, a senior team member． "We (80) need effective drugs for weight loss． (81) is a huge problem． We’re hoping to explore the possibilities of this new path．"he said．