Nose has it pretty hard, Boxers flatten them.
Doctors rearrange them. People make jokes about their unflattering
characteristics. Worst of all, when it comes to smell, no one really understands
them. Despite the nose’s conspicuous presence, its
workings are subtle. Smell, or olfaction, is a chemo-sense, relying on
specialized interactions between chemicals and nerve endings. When a rose, for
example, is sniffed, odor molecules are carried by the rising air-stream to the
top of the nasal cavity, just behind the bridge of the nose, where the tips of
the tends of millions of olfactory nerve cells are clustered in the mucous
lining. The molecules somehow trigger the nerve ending, white carry the message
to the olfactory lobes of the brain. Because smell information then travels to
other region of the brain, the scent of a rose can elicit not only a pleasure
sensation but emotions and memories as well. Though
just how odors stimulate the nerves is unknown, scientists do know that our
sense of smell is surprisingly keen capable of distinguishing up to tens of
thousands of chemical odors. The laboratory task of isolating the components
must of an odor is far from simple .Tobacco smoke, for example, is made up of
several thousand different chemicals. Moreover smell by their sources or
associations. Description such as "like a wet dog" or "like my elementary
school" may convey perceptions but are vastly inadequate for labeling the
chemistry involved. To further complicate research,
olfaction is connected to other sensations. Besides olfactory nerves, the nasal
cavity contains pain-sensitive nerves that perceive sensations such as the kick
in ammonia or the burning in chili peppers. Smell also inter-wines with taste to
create flavor. A coffee drinker holding his nose while sipping would taste only
the bitter in his brew, for taste receptors generally appear limited to bitter,
salty, sour, and sweet. The sense of smell is ten thousand times more sensitive
than taste and makes subtle distinctions among lemon, chocolate, and many more
flavors. So how does the nose manage this sophisticated
discrimination Lack of evidence hasn’t kept scientists from speculating. One
idea is that every odor molecule vibrates at its own frequency, creating
patterns of disturbance in the air similar to the wave patterns produced by
sound. According to this theory, the nerves act as receives for the unique
vibrations of every odor molecule. The scheme requires no direct contact between
the molecule and the nerve cell. Another suggestion is
that primary odors, equivalent to the primary colors of vision, underlie all
smells and are detected by receptor sites on the olfactory nerves. Different
combinations of about thirty basic smells, with labels such as malty, minty, and
musky, could form an infinite number of odors. Other
scientists think that each smell is its own primary smell. They believe the
olfactory nerve endings have specific receptor proteins that bind to each of the
chemicals people can sense. This theory, however, calls for thousands of
different proteins-none of which has been found. "The
science of smell is so empirical," says Robert Gesteland, a neurobiologist at
Northwestern University, "there is no predictive base for experiments." Unlike
the senses of sight, touch, and hearing, olfaction studies have attracted only a
small share of scientific interest. That may change. Researchers hope that
unraveling the mystery of smell will advance our understanding of the future,
with enough known about smell, it might be possible to endow strange,
unappealing but nutritious foods with more familiar odors, perhaps expanding the
world’s food supply. For the moment, however, what the nose knows it isn’t
revealing. The broadest example of a major problem facing smell researchers is
contained in______.
A. the reference to tobacco smoke
B. the reference to the rose
C. the coffee drinker’s experience
D. Robert Gesteland’s statement