The strands of the DNA molecule are antiparallel, which means that ( ).

A、both strands are oriented in a 5" to 3" direction
B、both strands are oriented in a 3" to 5" direction
C、the molecule is oriented differently from the rest of the cell
D、only one strand of the molecule replicates
E、one strand is oriented in a 5" to 3" direction and the other in a 3" to 5" direction