TEXT C Jonas Frisen had his
eureka moment in 1997. Back then, scientists suspected that there was a special
type of cell in the brain that had the power to give rise to new brain cells. If
they could harness these so-called neural stem cells to regenerate damaged brain
tissue, they might someday find a cure for such brain diseases as Alzheimer’s
and Parkinson’s. But first they had to figure out where neural stem cells were
and what they looked like. Frisen, then a freshly minted Ph. D. at the
Karolinska Institute in Stockholm, was peering through his microscope at some
tissue taken from a rat’s injured spinal cord when he saw cells that appeared to
have been enervated by the injury, as though they were busy making repairs.
Frisen thought these might be the neural stem cells scientists had been looking
for. It took him six years of painstaking research to make sure.
Frisen is quick to emphasize that his research is basic and that
treatments are years off. But the findings so far hint at extraordinary
potential. Two years ago he identified neural stem cells in the adult
humanbrain. And he’s now researching the mechanisms by which these ceils grow
into different types of brain cells. Rather than growing brain tissue in a petri
dish and implanting it in, say, the forebrain of a Parkinson’s patient, doctors
might someday stimulate the spontaneous growth of new neural ceils merely by
administering a drug. "It sounds like science fiction," Frisen says, "but we can
already do it in mice." In 2007 he will publish the results of his recent
experiments, lie’s isolated a protein in the mouse brain that inhibits the
generation of nerve cells. Using other chemicals, he’s been able to block the
action of this inhibitor, which in turn leads to the production of new brain
cells. Frisen honed his analytical mind at the dinner table in
Goteborg, in southwest Sweden. His mother was a mathematics professor and his
father was an ophthalmologist. Frisen went to medical school intending to be a
brain surgeon or perhaps a psychiatrist, but ended up spending all his free time
in the lab. In 1998 he got seed money from a Swedish venture capitalist to set
up his own company, NeuroNova, to commercialize his work. A private foundation
tried to lure him to Texas, but Swedish businessman Marcus Storch persuaded him
to stay by funding a IS-year professorship at Karolinska, covering his salary
and the running costs of his 15-person lab. "Jonas Frisen stood out from all
candidates by far," says Storch, who*Ic Tobias Foundation sponsors stem-cell
research. "He is something of a king in Sweden." Two years ago two more venture
capitalists helped the company expand by hiring a CEO and setting up a separate
lab. Since most researchers are interested in stem cells taken
from embryos, the practice has attracted considerable controversy in the past
few years. Frisen has benefited indirectly from research restrictions in the
United States, which have driven funds and brain-power to Singapore, the United
Kingdom and Sweden. The Bush Administration currently forbids U. S. -funded work
on all but 78 approved stem-cell cultures, many of which are located outside the
country. In just one sign of the times, the U. S. -based Juvenile Diabetes
Research Foundation recently announced grants totaling $ 20 million for stem
cell research--the largest award yet given to the field by a medical charity--to
research institutes in Sweden and elsewhere, but not in the United
States. Since Frisen doesn’t work with embryonic stem cells,
he’s unwittingly become a champion of the radical right, which argues that
scientists ought to concentrate solely on adult stem cells. He happens to
disagree. "It would be overoptimistic or outright stupid." he says. "To really
understand adult cells, we need to master how embryonic stem cells work." But
what really gets Frisen going is when people ask him when they can expect a drug
for Parkinson’s and other diseases. "I say, five decades, just to get the number
thing out of the way," he quips. "I’m not going to oversell this." When pressed,
he admits that clinical trials might begin in five years. That would be a eureka
moment worth waiting for. The main idea of the passage is ______.
A.Jonas Frisen’s research-has incurred much criticism from radical right. B.Jonas Frisen’s research on stem-cells hints at extraordinary potential. C.Jonas Frisen is trying to cure Parkinson’s and other neural diseases. D.Jonas Frisen’s research will relieve many patients of their sufferings.