TEXT D Last year, when President
George W. Bush announced that federal funds could be used to support re search
on human embryonic stem cells, he mandated that only those cell lines that
existed at the time would qualify for such support. More than a year later it’s
becoming increasingly clear that these existing cell lines are inadequate.
Unless more are created, the research slowdown may exact a staggering cost in
terms of human suffering. Since this announcement, the U. S
National Institutes of Health has tried to stimulate research on the existing
cell lines with new funding and efforts to streamline the initially cumbersome
process of obtaining approved cells. However, whether there are 60 cell lines,
as originally stated, or nine, as now appear to be available to NIH-funded
investigators, the number is not adequate. Given the genetic diversity within
the population, scientists need access to new cell lines if they are to come up
with the most effective cell therapies. The issue is partly one
of safety. In conducting research with human participants, we must minimize
risks. The most effective cell line might not be the safest. When developing a
new medicine, a large number of molecules must be screened to find a balance
between effectiveness and safety. The same is true with cells: In the context of
cell therapy, it will be important to minimize unwanted immune reactions and
inflammation. This requires selection from a large number of cell lines to
obtain the best match. It’s clear from experiments with animals
that stem--cell therapies can reduce human suffering. Parkinsonian mice have
been cured with embryonic stem cells that were programmed to become
dopamine-secreting, replacement nerve cells. Soon, cells induced to make insulin
in tissue cultures will be used in attempts to treat diabetic mice. Similar
successes have been achieved in animal models of spinal cord injury, heart
failure and other degenerative disorders. We are at a frontier in medicine where
tissues will be re stored in ways that were not imaginable just a few years ago.
The ethical issues raised by human-embryo research are profound. The human costs
of restricting this research must be taken into account as well. The cost in
dollars of delaying new stem-cell research is difficult to estimate. It might
measure in the hundreds of billions of dollars, especially if one adds the lost
productivity of individuals who must leave work to care for victims of
degenerative disorders. A less obvious, but real, cost is the
damage to the fabric of America’s extraordinary culture of inquiry and technical
development in biomedical science. Our universities and teaching hospitals are
unparalleled. We attract the very best students, scientists and physicians from
around the world. But these institutions are fragile. Research and education
play key roles in attracting the best physicians. A crippled research enterprise
might add an unbearable stress with long-lasting effects on the entire system.
If revolutionary new therapies are delayed or outlawed, we could be set back for
years, if not decades. To steer clear of controversy, some
investigators will redirect their research. Others will emigrate to countries
where such research is allowed and encouraged. Some will drop out entirely. The
pall cast over the science community could extend far beyond stem-cell research.
Many therapies have emerged from collaboration between government-sponsored
researchers and private enterprise. Few of these discoveries would have
emerged ii, for instance, recombinant DNA research had been outlawed 30 years
ago. We face the same type of decision today with limits placed on human
embryonic stem cells. Safeguards will be necessary. But if we do
not proceed embracing the values of objective, open, inquiry with complete
sharing of methods and results, the field will be left to less rigorous fringe
groups here and abroad. Patients and society will suffer. Which of the following statements about the research is TRUE
A.Some researchers are dubious of the feasibility of the research. B.Private enterprise doesn’t show the interest in the research. C.There should be a balance between caution and audacity. D.Many researchers have given up their research.