单项选择题

Vivid, violent dreams can portend brain disorders by half a century, a new study finds. Spotting early warning signs of the disease may (67) clinicians to monitor and treat patients long (68) the brain deterio-rates. People with a mysterious sleep disturbance (69) REM sleep behavior disorder, or RBD, experience a sudden change in the nature of dreams. Dreams increasingly become more violent and frequently (70) episodes in which an attacker must be fought (71) . The normal muscle paralysis that accompanies dreams is gone, (72) the dreamer, who is most often male, to act (73) the dream’s punches, twists and yells.
Doctors used to think of RBD as an isolated disorder. But follow-up studies (74) that a striking number of these patients later (75) neuro-degen-erative diseases, including Parkinson’s disease and Lewy body dementia. The exact figures (76) , but some studies find that anywhere from 80 to 100 percent (77) get a neurodegenerative disorder.
In a study, 27 patients who (78) the criteria (of which only three were women, (79) the curious male pre-dominance of RBD), the median interval (80) onset of the sleep disorder and of the neurological disorder was 25 years. (81) six of these patients the sleep disorder was first (82) by their spouse on their honeymoon or shortly afterwards. In one case, RBD (83) Parkinson’s disease by 50 years.
The researchers can’t (84) how frequently this happens in the general population, because patients were (85) to have a minimum interval of 15 years between the onset of RBD and diagnosis of neurodegenerative disease. But (86) such long intervals between diseases were unexpected.

(82) should choose （）

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