Dolly was once an awfully lonely sheep.When the
famous cloned (of an exact copy of a plant or animal made by taking a cell from
it and developing it artificially) animal made headlines in 1997,she was the
only mammal ever to be manufactured from the cell of an adult donor.Since
then,the clone ranks have swelled,with mice and cattle also making their way out
of the labs.Last week cloning technology took another step forward when an
international biotechnology company announced that it had created a litter of
five genetically identical piglets (young pigs),and that it had a pretty good
idea of how they could one day be used:as organ donors for ailing
humans. The idea of turning pigs into tissue factories has been
around for at least 30 years.Pigs breed easily and mature quickly,and their
organs are roughly the same size as those of humans,meaning operations can be
performed with a relative snap-out,snap-in simplicity.The problem is,once the
donor organ is stitched in place,the body rebels,rejecting it even more
violently than it would a human transplant.“A pig heart transplanted in a person
would turn black within minutes.” says David Ayares,a research director with PPL
Therapeutics,the biotech firm that helped clone Dolly and also produced the
piglets. What causes pig organs to be rejected so quickly is a
sugar molecule on the surface of pig cells that identifies the tissue as
unmistakably nonhuman.When the immune system spots this marker,it calls out its
defenses.PPL scientists recently succeeded in finding the gene responsible for
the sugar and knocking it out of the nucleus of a pig cell.Their next step would
be to extract that nucleus,insert it into a pig ovum,and then into the womb of a
host pig.The sugar free piglet that was eventually born could then be cloned
over and over as a source of safe transplant organs.The idea is to arrive at the
ideal animal and repeatedly copy it exactly as it is.The cloned piglets PPL
introduced to the world last week were created in just this way,though for this
first experiment in pig replication the scientists left the sugar genes
intact. Despite this recent success,PPL is not likely to be
setting up its organ shop anytime soon.Knocking out the key sugar gene solves
only the problem of short-term rejection.Much more has to be done before any
solution to long-term rejection can be rotund.Nonetheless,Ayares is
optimistic,insisting that pig organs could be available in as little as five
years.For the present,even a little new transplant material is a big improvement
over what’s available,and for gravely ill patients awaiting a donor,that’s no
small thing. The text is probably written as______.
A. a report of scientific progress to the general public.
B. an academic discussion of new possibilities in genetic science.
C. an argument for using pigs over sheep as transplant materials.
D. a look into advantages and disadvantages of cloning technology.